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Treatment strategies for polycythemia vera: Observations in a Dutch "real-world" cohort study. Thromboembolic events in polycythemia vera. Prognosis and treatment of polycythemia vera. Polycythemia vera treatment algorithm 2018. cancer-related updates too, such as a book or activity the child enjoyed. Polycythemia vera-associated complications: Pathogenesis, clinical manifestations, and effects on outcomes. went through the same type of leukemia just a. Polycythemia vera, essential thrombocythemia, and primary myelofibrosis. National Heart, Lung, and Blood Institute. In rare cases, polycythemia vera can lead to other blood diseases, including a progressive disorder in which bone marrow is replaced with scar tissue, a condition in which stem cells don't mature or function properly, or cancer of the blood and bone marrow (acute leukemia). Too many red blood cells can lead to a number of other complications, including open sores on the inside lining of your stomach, upper small intestine or esophagus (peptic ulcers) and inflammation in your joints (gout). Problems due to high levels of red blood cells.The increased number of blood cells caused by polycythemia vera makes your spleen work harder than normal, which causes it to enlarge. Your spleen helps your body fight infection and filter unwanted material, such as old or damaged blood cells. Blood clots can cause a stroke, a heart attack, or a blockage in an artery in your lungs or a vein deep within a leg muscle or in the abdomen. Increased blood thickness and decreased blood flow, as well as abnormalities in your platelets, raise your risk of blood clots. Possible complications of polycythemia vera include: Men are more likely to get polycythemia vera, but women tend to get the disease at younger ages. Polycythemia vera can occur at any age, but it's more common in adults between 50 and 75. The cause of the gene mutation in polycythemia vera is unknown, but it's generally not inherited from your parents. But in polycythemia vera, your bone marrow makes too many of some of these blood cells.

Normally, your body regulates the number of each of the three types of blood cells you have - red blood cells, white blood cells and platelets. Polycythemia vera occurs when a mutation in a gene causes a problem with blood cell production.